Value chain CAR-T Cell

Research and Development
In Vitro

Preclinical Development
In Vivo

Manufacturing and Clinical trials

Patient

Analytical Process, Quality assement, Quality Control arrow_drop_down
  • Cleaning
  • CGMP
  • Cross contamination
  • Sterility
  • Deviations
  • Quality control
  • Contaminants detection
  • Safety for gene-edited cells : translocation
  • Safety for gene-edited cells : anti-nuclease response
  • Safety for gene-edited cells : cytokine-independent growth
CMC
Targer Identification
Gene modification
Gene Delivery system arrow_drop_down
  • Lentivirus
  • Retrovirus
  • Adeno-Associated Virus (AAV)
  • Adenovirus (ADV)
  • Gene Gun
  • Electroporation
  • Lipid chemical methods
  • Protein chemical methods
  • Mixed chemical methods
  • Inorganic methods
Biomarker Identificaton
scFv Generation arrow_drop_down
  • Mouse immunisation
  • Phae Display
  • In Silico
  • Hybridome
CAR Construction arrow_drop_down
  • Intracellular Domain
  • T-cell activation/transduction
  • Engineering : Tandem CAR
  • Engineering : iCAR
  • Engineering : Ab-coupled TCR (ATCR)
Adoptive T cell Major Challenges in Solid Tumors arrow_drop_down
  • Tumor/Ag heterogeneity
  • Tumor associated Antigen
  • Miroenvironment
  • Delivery/homing
  • Combinations
Bioproduction arrow_drop_down
  • Bioproduction
  • Scale-Up
  • Automate manufacturing
  • Automated high-throughput microbioreactor system
  • Supply chain logistics
  • Tracking process
  • Monitoring logistics
  • Non-GMP pilot batch
  • GMP batch
Ex Vivo & In Vivo Strategy
Cell acquisition arrow_drop_down
  • Autologus
  • Allogenic
  • Cell Bank
  • Tissue acquisition
  • Off the shelf
  • Apheresis
Target cell isolation arrow_drop_down
  • iPS reprogrammation
  • Differentiated Cell
  • Production Cell
  • Safety donor-derived therapies
Cell modification arrow_drop_down
  • Gene modifcation
  • Directed reprogrammation
  • Construct introduction
Cell Expansion arrow_drop_down
  • Bioreacteur
  • Wave
  • Cell factory
  • Other
Purification / extraction
Formulation
Conditionning
Transport

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Companies

Aenitis Technologies

Equipment supplier

Aenitis develops innovative patented devices for the continuous handling, without contact or pressure, of suspended cells by the use of acoustic radiation forces (called acoustophoresis). Aenitis focuses on the development and sales of medical devices and lab instruments addressing bioproduction preparation issues in cell and gene therapy.

Mitry-Mory
France

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CELLQUEST

Manufacturer

Service company

Equipment supplier

MARCHAUX
France

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Centre MEARY

Manufacturer

Research structure

AP-HP MEARY Center for Cell and Gene Therapy is among the leaders in the manufacturing of ATMPs, offering cutting-edge expertise to clinicians, research teams, as well as industrial partners for the support and execution of their cell, tissue, and gene therapy clinical trials.

PARIS
France

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CHU de Rouen

Manufacturer

Research structure

University hospital of Rouen Normandy advanced therapy facility NORMAcell

Rouen
France

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CITHERA

Manufacturer

Research structure


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CTIBiotech

Service company

Research structure

Company specializing in dermatocosmetics and oncology research, in particular through 3D bioprinting of complex models and in-house testing. Bio-bank accredited to the Ministry of Education and Research, with more than 50,000 samples in stock and a network of 200 partners.

Meyzieu
France

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Etablissement Français du Sang

Manufacturer

Service company

Research structure

The EFS is the sole player in transfusion in France. In addition to its activities of collection, preparation, qualification and distribution of Labile Blood Products (PSL), EFS is a major player in cell and tissue therapies and in the design and production of MTI. Its CDMO activity offers clinical batch production capacities on several platforms.

St Denis
France

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Harmonic Pharma

Service company

HARMONIC PHARMA is a deeptech providing the pharmaceutical, chemistry, biotechnology, cosmetics and nutraceutical industry with customized services during compound development projects. HARMONIC PHARMA has developped In Silico predictions tools tailored to profile a compound activity and/or toxicity.

Nancy
France

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IPRASENSE

Equipment supplier

IPRASENSE provides cell analysers for real-time monitoring of cell cultures. Our SME, based in the Montpellier area, relies on expertise in holographic imaging acquired with CEA Leti since its creation in 2013. Our instruments focus on both the academic research and the pharmaceutical industry from the cell line development stages up to the bioproduction in GMP environment.

Clapiers
France

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IPSIRIUS

Manufacturer


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Keyrus Life Science

Service company

Keyrus Life Science is a unique Connected Clinical Research & Development Organization. We believe that it is only by making sense of data that mankind can solve the major health challenges it faces. Keyrus Life Science helps connect industry expertise, Life Data Sciences and Digital Enablement to fully leverage both Clinical Research ecosystems and Real-World Evidence/RWE in healthcare, thus enhancing the reliability, innovative capacity, agility, and, above all, speed of execution of Clinical Research activities.

Levallois-Perret
France

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LinBox

Service company

With more than 40 years of experience in cryopreservation, quality and regulatory affairs, LinBox can propose solutions related to biobanks and tissues and cells grafts’ cryopreservation.

Bailly Romainvilliers
France

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Sangamo Therapeutics France

Research structure

Sangamo Therapeutics is committed to translating ground-breaking science into genomic medicines with the potential to transform patients’ lives using gene therapy, ex vivo gene-edited cell therapy, and in vivo genome editing and gene regulation. Sangamo Therapeutics France is the French subsidiary of Sangamo Therapeutics. Its actitivies are focused on ex vivo gene-edited cell therapy for the treatment of inflammatory and autoimmune diseases.

VALBONNE
France

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tebu-bio

Manufacturer

Service company

The strength of our distribution activity through the pan-European branches of our group, lies in our longstanding relationships with our suppliers. This allows us to provide first-rate service and to be the reliable source for reagents critical to our customers’ research and product development. In parallel, access to a broad selection of ethical sources, including collections of biological samples and primary cells, enables us to perform in vitro assays for understanding mechanisms of actions (MOA) and demonstrating proofs of concepts (POC) with a short turnaround time.

Le Perray en Yvelines
France

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Thermo Fisher Scientific

Manufacturer

Service company

Equipment supplier

Thermo Fisher Scientific is the world leader in serving science, with revenues of more than $24 billion and approximately 70,000 employees globally. Our mission is to enable our customers to make the world healthier, cleaner and safer.

Les Ulis
France

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